Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
Int J Cardiol
; 273: 100-107, 2018 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-30060970
ABSTRACT
BACKGROUND:
Hepatic and renal dysfunction have been observed in survivors of the Fontan procedure, however their incidence and associated factors remain poorly defined.METHODS:
A total of 152 participants from a Registry of 1528 patients underwent abdominal ultrasound, transient elastography (FibroScan), serum fibrosis score (FibroTest), in vivo Tc-99m DTPA measurement of glomerular filtration rate (mGFR), and urine albumin-creatinine ratio (ACR).RESULTS:
Mean age and time since Fontan were 19.8⯱â¯9.3 and 14.1⯱â¯7.6â¯years, respectively. Features suggestive of hepatic fibrosis were observed on ultrasound in 87/143 (61%) and no patient was diagnosed with hepatocellular carcinoma. FibroScan median kPa was ≥10 in 117/133 (88%), ≥15 in 75/133 (56%), and ≥20 in 41/133 (31%). Fifty-four patients (54/118, 46%) had a FibroTest score ≥0.49 (equivalent to ≥F2 fibrosis). FibroTest score correlated with FibroScan value (râ¯=â¯0.24, pâ¯=â¯0.015) and ACR (râ¯=â¯0.29, pâ¯=â¯0.002), and patients with ultrasound features of hepatic fibrosis had a higher FibroScan median kPa (19.5 vs 15.4, pâ¯=â¯0.002). Renal impairment was mild (mGFR 60-89â¯ml/min/1.73â¯m2) in 46/131 (35%) and moderate (mGFR 30-59â¯ml/min/1.73â¯m2) in 3/131 (2%). Microalbuminuria was detected in 52/139 participants (37%). By multivariable analysis, time since Fontan was associated with increased FibroScan median kPa (ßâ¯=â¯0.89, 95% CI 0.54-1.25, pâ¯=â¯0.002) and decreased mGFR (ßâ¯=â¯-0.77, 95% CI -1.29-0.24, pâ¯=â¯0.005).CONCLUSIONS:
In the second decade after Fontan hepatic and renal structure and function are abnormal in a significant number of patients close to 60% have ultrasonographic evidence of structural hepatic abnormalities, 46% have elevated serum hepatic fibrosis scores, and 57% have either reduced glomerular filtration rate or microalbuminuria. Hepatic and renal function should be monitored for potential impacts on outcomes after Fontan completion.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema de Registros
/
Técnica de Fontan
/
Relatório de Pesquisa
/
Rim
/
Fígado
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Oceania
Idioma:
En
Revista:
Int J Cardiol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália