Epigenetic Mechanisms Dictating Eradication of Cancer by Natural Killer Cells.
Trends Cancer
; 4(8): 553-566, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-30064663
ABSTRACT
Natural killer (NK) cells of the innate immune system are the first line of defense against infectious agents and cancer cells. However, only a few mechanisms that regulate eradication of tumors by NK cells have been identified. In this review, we present an account of epigenetic mechanisms that modulate the ability of NK cells to eradicate cancer cells. To date, several drugs that target epigenetic modifiers have shown clinical efficacy in cancer. Therefore, once a given epigenetic modifier is validated as a regulator of NK cell function, it can be targeted for NK cell-based cancer immunotherapies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Epigênese Genética
/
Imunoterapia
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Trends Cancer
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos