Glutathione peroxidase-1 overexpressing transgenic mice are protected from neurotoxicity induced by microcystin-leucine-arginine.

Shin, Eun-Joo; Hwang, Yeong Gwang; Pham, Duc Toan; Lee, Ji Won; Lee, Yu Jeung; Pyo, Dongjin; Jeong, Ji Hoon; Lei, Xin Gen; Kim, Hyoung-Chun

Shin, Eun-Joo; Hwang, Yeong Gwang; Pham, Duc Toan; Lee, Ji Won; Lee, Yu Jeung; Pyo, Dongjin; Jeong, Ji Hoon; Lei, Xin Gen; Kim, Hyoung-Chun.

Afiliação

Shin EJ; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Hwang YG; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Pham DT; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Lee JW; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Lee YJ; Clinical Pharmacy, College of Pharmacy, Kangwon National University, Republic of Korea.
Pyo D; Department of Chemistry, College of Natural Sciences, Kangwon National University, Republic of Korea.
Jeong JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Lei XG; Department of Animal Science, Cornell University, New York.
Kim HC; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.

Environ Toxicol ; 33(10): 1019-1028, 2018 Oct.

Article em En | MEDLINE | ID: mdl-30076769

Assuntos

Arginina/toxicidade; Glutationa Peroxidase/metabolismo; Hipocampo/efeitos dos fármacos; Leucina/toxicidade; Microcistinas/toxicidade; Aldeídos/análise; Animais; Regulação para Baixo/efeitos dos fármacos; Glutationa/metabolismo; Glutationa Peroxidase/genética; Hipocampo/metabolismo; Hipocampo/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; NF-kappa B/antagonistas & inibidores; NF-kappa B/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Carbonilação Proteica/efeitos dos fármacos; Pirrolidinas/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Superóxido Dismutase-1/metabolismo; Tiocarbamatos/farmacologia; Regulação para Cima/efeitos dos fármacos; Glutationa Peroxidase GPX1

Palavras-chave

GPx-1 overexpressing transgenic mice; NFκB; hippocampus; intracerebroventricular infusion; microcystin-leucine-arginine; neurotoxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Microcistinas / Glutationa Peroxidase / Hipocampo / Leucina Limite: Animals Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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