Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1.
Nanoscale
; 10(33): 15632-15640, 2018 Aug 23.
Article
em En
| MEDLINE
| ID: mdl-30090884
ABSTRACT
Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein - EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Herpesvirus Humano 4
/
Antígenos Nucleares do Vírus Epstein-Barr
/
Nanopartículas
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Neoplasias
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2018
Tipo de documento:
Article