Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix.
Clin Med Insights Oncol
; 12: 1179554918783990, 2018.
Article
em En
| MEDLINE
| ID: mdl-30093800
ABSTRACT
PURPOSE:
To evaluate clinical outcomes and failure patterns in patients with locally advanced cervical cancer (LACC) treated definitively using image-guided volumetric-modulated arc therapy (IG-VMAT). METHODS AND MATERIALS This retrospective review included 18 consecutively treated patients with LACC. Treatment consisted of IG-VMAT and concurrent chemotherapy followed by intracavitary radiotherapy. The primary end points were overall survival (OS) and disease-free survival (DFS). Acute haematologic toxicity was evaluated using Radiation Therapy Oncology Group (RTOG) criteria.RESULTS:
A total of 16 patients were either stage IIB or IIIB and the median follow-up was 30.5 months (interquartile range 13-36.25 months). The 2-year DFS was 63.3% (95% confidence interval [CI] 52.8%-72.4%) and 2-year OS was 72.2% (95% CI 62.1%-80.5%). There were 7 treatment failures, predominantly in-field. Acute haematologic toxicity was low.CONCLUSIONS:
IG-VMAT is associated with favourable outcomes for patients with LACC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Clin Med Insights Oncol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Índia