Early manifestation of depressive-like behavior in transgenic mice that express dementia with Lewy body-linked mutant ß-synuclein.
Neuropsychopharmacol Rep
; 38(2): 95-97, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-30106256
ABSTRACT
AIM:
We previously generated transgenic (Tg) mice that expressed P123H ß-synuclein (ßS), a dementia with Lewy body-linked mutant ßS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impairment. Since recent studies suggested that non-motor symptoms, such as depression, might be manifested in the prodromal stage of Lewy body disease, the main objective of the present study was to investigate the early expression of behavior in P123H ßS Tg mice.METHODS:
Nest building, locomotor activity, and depressive-like behavior were assessed using 6- to 10-month-old male and female P123H ßS Tg and wildtype mice. KEYRESULTS:
P123H ßS Tg mice exhibited hyperlocomotor activity in a novel environment, a decrease in mobility time in the tail suspension test, and impairments in nest building.CONCLUSIONS:
Importantly, these non-motor behaviors were manifested before the onset of motor dysfunction, suggesting that P123H ßS Tg mice could be a valid model for investigating the early phase of Lewy body disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mutação de Sentido Incorreto
/
Doença por Corpos de Lewy
/
Depressão
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Beta-Sinucleína
Limite:
Animals
Idioma:
En
Revista:
Neuropsychopharmacol Rep
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão