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Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Pettersson, Martin; Johnson, Douglas S; Rankic, Danica A; Kauffman, Gregory W; Am Ende, Christopher W; Butler, Todd W; Boscoe, Brian; Evrard, Edelweiss; Helal, Christopher J; Humphrey, John M; Stepan, Antonia F; Stiff, Cory M; Yang, Eddie; Xie, Longfei; Bales, Kelly R; Hajos-Korcsok, Eva; Jenkinson, Stephen; Pettersen, Betty; Pustilnik, Leslie R; Ramirez, David S; Steyn, Stefanus J; Wood, Kathleen M; Verhoest, Patrick R.
Afiliação
  • Pettersson M; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
  • Johnson DS; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
  • Rankic DA; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Kauffman GW; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
  • Am Ende CW; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Butler TW; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Boscoe B; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Evrard E; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
  • Helal CJ; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Humphrey JM; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Stepan AF; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
  • Stiff CM; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Yang E; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Xie L; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.
  • Bales KR; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA.
  • Hajos-Korcsok E; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA.
  • Jenkinson S; Global Safety Pharmacology , Pfizer Worldwide Research and Development , La Jolla , California 92121 , USA.
  • Pettersen B; Drug Safety R&D , Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , USA.
  • Pustilnik LR; Primary Pharmacology Group , Groton , Connecticut 06340 , USA.
  • Ramirez DS; Global Safety Pharmacology , Pfizer Worldwide Research and Development , La Jolla , California 92121 , USA.
  • Steyn SJ; Pharmacokinetics, Dynamics and Metabolism , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , USA.
  • Wood KM; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA.
  • Verhoest PR; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
Medchemcomm ; 8(4): 730-743, 2017 Apr 01.
Article em En | MEDLINE | ID: mdl-30108792
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Medchemcomm Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Medchemcomm Ano de publicação: 2017 Tipo de documento: Article