Biocompatible crosslinked ß-cyclodextrin nanoparticles as multifunctional carriers for cellular delivery.
Nanoscale
; 10(34): 16284-16292, 2018 Aug 30.
Article
em En
| MEDLINE
| ID: mdl-30128442
ABSTRACT
Nanoparticle-based biomedicine has received enormous attention for theranostic applications, as these systems are expected to overcome several drawbacks of conventional therapy. Herein, effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties are used as a versatile and powerful class of nanocarriers. We report the synthesis of a novel biocompatible and multifunctional material, entirely consisting of covalently crosslinked organic molecules. Specifically, ß-cyclodextrin (CD) precursors were crosslinked with rigid organic linker molecules to obtain small (â¼150 nm), thermally stable and highly water-dispersible nanoparticles with an accessible pore system containing ß-CD rings. The nanoparticles can be covalently labeled with dye molecules to allow effective tracking in in vitro cell experiments. Rapid sugar-mediated cell-uptake kinetics were observed with HeLa cells, revealing exceptional particle uptake within only 30 minutes. Additionally, the particles could be loaded with different cargo molecules showing pH-responsive release behavior. Successful nuclei staining with Hoechst 33342 dye and effective cell killing with doxorubicin cargo molecules were demonstrated in live-cell experiments, respectively. This novel nanocarrier concept provides a promising platform for the development of controllable and highly biocompatible theranostic systems.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Beta-Ciclodextrinas
/
Nanopartículas
Limite:
Humans
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2018
Tipo de documento:
Article