[Effect of Heat-Clearing and Detoxifying Health Function of Lonicera japonica in Rats Based on Metabonomics].
Zhong Yao Cai
; 39(5): 1129-33, 2016 May.
Article
em Zh
| MEDLINE
| ID: mdl-30133198
ABSTRACT
Objective:
To study the metabonomics for heat-clearing and detoxifying health function of Lonicera japonica in rats.Methods:
Male Wistar rats were treated with decoction of Lonicera japonica through intragastric for 5 d. GC-MS was used to detect the changes in rats serum metabolites. Mass spectrometry analysis,PCA and other technologies were used to analyze the differences among their metabolites,and analyzed the endogenous product.Results:
There was a decline trend in citric acid cycle intermediates of Lonicera japonica treated group. On the contrary,amino acids and fatty acid intermediate product showed significant elevation,which revealed that the pathway of tricarboxylic acid cycle has been inhibited,and consistented with heat-clearing and detoxifying effect of Lonicera japonica.Conclusion:
The metabonomics method by detecting the low-molecular-weight compounds can evaluate the heat-clearing and detoxifying health function of Lonicera japonica.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lonicera
/
Metabolômica
Limite:
Animals
Idioma:
Zh
Revista:
Zhong Yao Cai
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2016
Tipo de documento:
Article