Cutaneous Vasculitis in Cogan's Syndrome: A Report of Two Cases Associated with Chlamydia Infection.
J Nippon Med Sch
; 85(3): 172-177, 2018.
Article
em En
| MEDLINE
| ID: mdl-30135344
ABSTRACT
Cogan's syndrome (CS) is defined by the combination of hearing loss, vertigo, and ocular inflammation of uncertain cause, and can be associated with variable vessel vasculitis. Vasculitic manifestations may include arteritis (affecting large, medium or small arteries), aortitis, and aortic and mitral valvulitis. Cutaneous manifestations including erythema, papules, subcutaneous nodules, and purpura sometimes occur; however, to date, only six cases have been histologically confirmed to have genuine vasculitis. Here, we report two cases of CS, one of which involved a patient who developed the typical symptoms of Takayasu arteritis and purpuric lesions in the legs, with histologic findings consistent with small vessel vaculitis in the dermis. The second case involved a patient who developed subcutaneous nodules in the legs and the axilla, and histologic findings revealed a necrotizing vasculitis of the small arteries in the interlobular area. Both cases were successfully treated with systemic steroid therapy. Based on the clinical features and the examination data, there is a possibility that a Chlamydia trachomatis infection played a pivotal role in the pathogenesis of those vasculitides.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliarterite Nodosa
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Infecções por Chlamydia
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Arterite de Takayasu
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Vasculite Leucocitoclástica Cutânea
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Síndrome de Cogan
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
J Nippon Med Sch
Assunto da revista:
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article