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Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt.
Meteleva, E S; Chistyachenko, Yu S; Suntsova, L P; Tsyganov, M A; Vishnivetskaya, G B; Avgustinovich, D F; Khvostov, M V; Polyakov, N E; Tolstikova, T G; Mordvinov, V A; Dushkin, A V; Lyakhov, N Z.
Afiliação
  • Meteleva ES; Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630128, Russia.
  • Chistyachenko YS; Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630128, Russia.
  • Suntsova LP; Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630128, Russia.
  • Tsyganov MA; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
  • Vishnivetskaya GB; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
  • Avgustinovich DF; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
  • Khvostov MV; Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
  • Polyakov NE; Novosibirsk State University, Novosibirsk, 630090, Russia.
  • Tolstikova TG; Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
  • Mordvinov VA; Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
  • Dushkin AV; Novosibirsk State University, Novosibirsk, 630090, Russia.
  • Lyakhov NZ; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Dokl Biochem Biophys ; 481(1): 228-231, 2018 Jul.
Article em En | MEDLINE | ID: mdl-30168067
ABSTRACT
The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Opistorquíase / Praziquantel / Ácido Glicirrízico / Fenômenos Mecânicos / Antiplatelmínticos Limite: Animals Idioma: En Revista: Dokl Biochem Biophys Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Federação Russa
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Opistorquíase / Praziquantel / Ácido Glicirrízico / Fenômenos Mecânicos / Antiplatelmínticos Limite: Animals Idioma: En Revista: Dokl Biochem Biophys Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Federação Russa