DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?
Radiat Prot Dosimetry
; 182(1): 67-79, 2018 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-30169846
ABSTRACT
Single dose of potassium iodide (KI) is recommended to prevent the risk of thyroid cancer during nuclear accidents. However in the case of repeated/protracted radioiodine release, a unique dose of KI may not protect efficiently the thyroid against the risk of further developing a radiation-induced cancer. The new WHO guidelines for the use in planning for and responding to radiological and nuclear emergencies identify the need of more data on this subject as one of the four research priorities. The aims of the PRIODAC project are (1) to assess the associated side effects of repeated intakes of KI, (2) to better understand the molecular mechanisms regulating the metabolism of iodine, (3) to revise the regulatory French marketing authorization of 65-mg KI tablets and (4) to develop new recommendations related to the administration of KI toward a better international harmonization. A review of the literature and the preliminary data are presented here.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Iodeto de Potássio
/
Lesões por Radiação
/
Neoplasias da Glândula Tireoide
/
Liberação Nociva de Radioativos
/
Radioisótopos do Iodo
/
Neoplasias Induzidas por Radiação
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Radiat Prot Dosimetry
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França