Neratinib augments the lethality of [regorafenib + sildenafil].

Booth, Laurence; Roberts, Jane L; Rais, Rumeesa; Cutler, Richard E; Diala, Irmina; Lalani, Alshad S; Hancock, John F; Poklepovic, Andrew; Dent, Paul

Booth, Laurence; Roberts, Jane L; Rais, Rumeesa; Cutler, Richard E; Diala, Irmina; Lalani, Alshad S; Hancock, John F; Poklepovic, Andrew; Dent, Paul.

Afiliação

Booth L; Departments of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
Roberts JL; Departments of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
Rais R; Departments of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
Cutler RE; Puma Biotechnology Inc., Los Angeles, California, University of Texas Health Science Center, Houston, Texas.
Diala I; Puma Biotechnology Inc., Los Angeles, California, University of Texas Health Science Center, Houston, Texas.
Lalani AS; Puma Biotechnology Inc., Los Angeles, California, University of Texas Health Science Center, Houston, Texas.
Hancock JF; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas.
Poklepovic A; Medicine, Virginia Commonwealth University, Richmond, Virginia.
Dent P; Departments of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.

J Cell Physiol ; 234(4): 4874-4887, 2019 04.

Article em En | MEDLINE | ID: mdl-30203445

Assuntos

Antineoplásicos/farmacologia; Neoplasias Colorretais/tratamento farmacológico; Compostos de Fenilureia/farmacologia; Piridinas/farmacologia; Quinolinas/farmacologia; Citrato de Sildenafila/farmacologia; Proteínas Quinases Ativadas por AMP/metabolismo; Animais; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Linhagem Celular Tumoral; Sinergismo Farmacológico; Feminino; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Inibidores da Fosfodiesterase 5/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

DNA damage; HDAC; autophagy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Piridinas / Quinolinas / Neoplasias Colorretais / Citrato de Sildenafila / Antineoplásicos Limite: Animals Idioma: En Revista: J Cell Physiol Ano de publicação: 2019 Tipo de documento: Article

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