Age-Related Chromosomal Aberrations in Patients with Diffuse Large B-Cell Lymphoma: An In Silico Approach.
World J Oncol
; 9(4): 97-103, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-30220946
ABSTRACT
Background:
In diffuse large B-cell lymphoma (DLBCL), chromosomal aberrations are known to increase with advancing age. Our study aims to determine if there are other genetic aberrations associated with DLBCL based on age.Methods:
Using the Mitelman Database of Genetic Aberrations, we were able to find 749 cases of DLBCL with genomic aberrations with a median age of 62 years. Patients with DLBCL chromosomal aberration analysis results were divided into four groups based on age (0 - 30, 31 - 50, 51 - 70, > 71 years) and examined by chi-square analysis and Mantel-Cox for survival analysis.Results:
Ten aberrations were found to be significant with a particular age range t(2;3), trisomy 19p13, trisomy 18q21, trisomy 3, trisomy 7, trisomy 14, trisomy 16, trisomy 18, monosomy 3 and monosomy 11, and survival ranged from 7 to 25 months.Conclusion:
This suggests that patients with DLBCL are likely to accumulate specific translocations depending on their age at the onset of DLBCL.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
World J Oncol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos