Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long-Term Neurodevelopment.
J Clin Pharmacol
; 58 Suppl 10: S140-S150, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30248203
ABSTRACT
Inadequate pain and/or stress management in preterm- and term-born infants has been associated with increased morbidity and even mortality. However, exposure to analgosedatives during early infancy may also be one of the risk factors for subsequent neurodevelopmental impairment, at least in animal studies. Because infants admitted to neonatal or pediatric intensive care units may receive high amounts of these drugs for prolonged periods of time and the majority of these infants nowadays survive to discharge, this is of major concern. A balanced approach that incorporates the assessment and quantification of both wanted effects as well as unwanted side effects is therefore needed. In this article, the optimal dose determination of commonly used analgosedative drugs as well as their potential long-term effects on the developing human brain and neuropsychological functioning are reviewed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Encéfalo
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Desenvolvimento Infantil
/
Analgésicos
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Hipnóticos e Sedativos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Humans
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Infant
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Newborn
Idioma:
En
Revista:
J Clin Pharmacol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Holanda