Analysis for risk factors of 12-month neurological worsening in patients with surgically treated small-to-moderate size unruptured intracranial aneurysms.
J Clin Neurosci
; 58: 160-164, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30279118
ABSTRACT
The risk associated with surgical treatment for small-to-moderate size unruptured intracranial aneurysms (SMUIAs, defined as <15â¯mm) has not been well characterized. Authors aimed to investigate risk factors for poor outcome in surgical treatment of SMUIAs. The data of prospectively collected 801 consecutive patients harboring 971 surgically treated SMUIAs was evaluated. Neurological worsening (NW) was defined as an increase in 1 or more modified Rankin Scale at 12-month. Clinical and radiological characteristics were compared. Neurological worsening was observed in 45 (4.6%). In multivariate analysis, only perforator territory infarction (PTI) on postoperative diffusion-weighted imaging (odds ratio (OR), 13; 95% confidence interval (CI), 4.9-32, pâ¯<â¯0.0001), and aneurysm locations (paraclinoid (OR, 6.9; 95% CI, 3.1-15, pâ¯<â¯0.0001), basilar artery (OR, 4.5; 95% CI, 1.5-14, pâ¯=â¯0.008), vertebral artery (OR, 11; 95% CI, 3.3-34, pâ¯<â¯0.0001)) were related to neurological worsening. Multivariate analysis showed that statin use (OR, 12; 95% CI, 3.8-39, pâ¯<â¯0.0001) and aneurysm locations (internal carotid artery-posterior communicating artery (OR, 3.9; 95% CI, 1.8-8.2, pâ¯<â¯0.0001) and basilar artery (OR, 6.3; 95% CI, 2.3-17, pâ¯=â¯0.008)), and aneurysm size >10â¯mm (OR, 5.3; 95% CI, 1.8-15, pâ¯=â¯0.003) were related to PTI. Although all SMUIAs should be carefully considered whether to be treated, those with statins, specific locations, and larger sizes should perhaps be more meticulously contemplated, and neurosurgeons should continue to avoid PTI.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Aneurisma Intracraniano
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Clin Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão