Bone Marrow-Derived CD4<sup>+</sup> T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir.

Hoang, Timothy N; Harper, Justin L; Pino, Maria; Wang, Hong; Micci, Luca; King, Colin T; McGary, Colleen S; McBrien, Julia B; Cervasi, Barbara; Silvestri, Guido; Paiardini, Mirko

Bone Marrow-Derived CD4⁺ T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir.

Hoang, Timothy N; Harper, Justin L; Pino, Maria; Wang, Hong; Micci, Luca; King, Colin T; McGary, Colleen S; McBrien, Julia B; Cervasi, Barbara; Silvestri, Guido; Paiardini, Mirko.

Afiliação

Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Wang H; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Micci L; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
King CT; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
McGary CS; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
McBrien JB; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Cervasi B; Flow Cytometry Core, Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.
Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Paiardini M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.

J Virol ; 93(1)2019 01 01.

Article em En | MEDLINE | ID: mdl-30305357

Assuntos

Células da Medula Óssea/imunologia; Linfócitos T CD4-Positivos/metabolismo; Síndrome de Imunodeficiência Adquirida dos Símios/virologia; Vírus da Imunodeficiência Símia/patogenicidade; Animais; Antirretrovirais/uso terapêutico; Células da Medula Óssea/virologia; Linfócitos T CD4-Positivos/virologia; Antígeno CTLA-4/metabolismo; Macaca mulatta; Masculino; Receptor de Morte Celular Programada 1/metabolismo; Síndrome de Imunodeficiência Adquirida dos Símios/imunologia; Vírus da Imunodeficiência Símia/imunologia; Carga Viral/efeitos dos fármacos; Replicação Viral/efeitos dos fármacos

Palavras-chave

CTLA-4; HIV-1; PD-1; SIV; bone marrow; coinhibitory receptors; viral reservoir

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células da Medula Óssea / Linfócitos T CD4-Positivos / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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