Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg<sup>2+</sup>, spermine, and pH.

Zhelay, Tetyana; Wieczerzak, Krystyna B; Beesetty, Pavani; Alter, Gerald M; Matsushita, Masayuki; Kozak, J Ashot

Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg²⁺, spermine, and pH.

Zhelay, Tetyana; Wieczerzak, Krystyna B; Beesetty, Pavani; Alter, Gerald M; Matsushita, Masayuki; Kozak, J Ashot.

Afiliação

Zhelay T; From the Departments of Neuroscience, Cell Biology, and Physiology and.
Wieczerzak KB; From the Departments of Neuroscience, Cell Biology, and Physiology and.
Beesetty P; From the Departments of Neuroscience, Cell Biology, and Physiology and.
Alter GM; Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio 45435 and.
Matsushita M; the Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan.
Kozak JA; From the Departments of Neuroscience, Cell Biology, and Physiology and. Electronic address: juliusz.kozak@wright.edu.

J Biol Chem ; 293(47): 18151-18167, 2018 11 23.

Article em En | MEDLINE | ID: mdl-30305398

Assuntos

Membrana Celular/metabolismo; Citosol/metabolismo; Magnésio/metabolismo; Fosfatidilinositóis/metabolismo; Espermina/metabolismo; Canais de Cátion TRPM/metabolismo; Animais; Transporte Biológico; Membrana Celular/genética; Concentração de Íons de Hidrogênio; Camundongos; Técnicas de Patch-Clamp; Fosfatidilinositol 4,5-Difosfato/metabolismo; Poliaminas/metabolismo; Prótons; Canais de Cátion TRPM/genética

Palavras-chave

TRPM; channel activation; gain-of-function mutation; magnesium; mutant; phosphoinositide; polyamine; transfection; transient receptor potential channels (TRP channels); voltage-sensitive phosphatase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilinositóis / Espermina / Membrana Celular / Citosol / Canais de Cátion TRPM / Magnésio Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article

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