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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum ß-Lactamases and Carbapenemases.
Jacobs, Michael R; Abdelhamed, Ayman M; Good, Caryn E; Rhoads, Daniel D; Hujer, Kristine M; Hujer, Andrea M; Domitrovic, T Nicholas; Rudin, Susan D; Richter, Sandra S; van Duin, David; Kreiswirth, Barry N; Greco, Chris; Fouts, Derrick E; Bonomo, Robert A.
Afiliação
  • Jacobs MR; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA mrj6@case.edu robert.bonomo@va.gov.
  • Abdelhamed AM; Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
  • Good CE; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Rhoads DD; Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
  • Hujer KM; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Hujer AM; Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
  • Domitrovic TN; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Rudin SD; Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
  • Richter SS; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • van Duin D; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Kreiswirth BN; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Greco C; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Fouts DE; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Bonomo RA; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Antimicrob Agents Chemother ; 63(1)2019 01.
Article em En | MEDLINE | ID: mdl-30323050
ABSTRACT
The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Beta-Lactamases / Cefalosporinas / Stenotrophomonas maltophilia / Acinetobacter baumannii / Enterobacteriaceae / Antibacterianos Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Beta-Lactamases / Cefalosporinas / Stenotrophomonas maltophilia / Acinetobacter baumannii / Enterobacteriaceae / Antibacterianos Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article