Atezolizumab-induced sarcoid-like granulomatous reaction in a patient with urothelial cell carcinoma.
Immunotherapy
; 10(14): 1189-1192, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30326785
ABSTRACT
A 61-year-old woman with locally advanced, high-grade urothelial cell carcinoma was treated with the anti-programmed death-ligand 1 antibody atezolizumab. She initially received neoadjuvant chemotherapy and surgery that led to clinical and radiographic remission at the time of atezolizumab initiation. Within 3 months she developed new mediastinal and hilar lymphadenopathy as well as pulmonary nodules in a pattern characteristic of pulmonary sarcoidosis. Mediastinal lymph node biopsy by endobronchial ultrasound demonstrated noncaseating granulomas without evidence of malignancy or infection. Within 4 weeks of initiation of prednisone and cessation of atezolizumab there was marked reduction in intrathoracic lymphadenopathy and perilymphatic nodules. This is the first reported case of atezolizumab-induced sarcoid-like granulomatous reaction.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoidose Pulmonar
/
Urotélio
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Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Granuloma
/
Imunoterapia
/
Neoplasias Renais
/
Linfonodos
/
Anticorpos Monoclonais
/
Antineoplásicos
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Immunotherapy
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá