The endogenous retrovirus Mtv-8 on mouse chromosome 6 maps near several kappa light chain markers.
Immunogenetics
; 25(4): 222-7, 1987.
Article
em En
| MEDLINE
| ID: mdl-3032783
ABSTRACT
Endogenous retroviruses are known to affect expression of cellular genes in the vicinity of their integration sites. The endogenous mouse mammary tumor provirus (Mtv-8) previously has been reported to reside on mouse chromosome 6 near the immunoglobulin kappa chain locus. Using pairs of mouse strains on the BALB/c (Mtv-8 positive) and C58 (Mtv-8 negative) backgrounds which are congenic for chromosome 6 genetic markers, we have confirmed the chromosome assignment of this provirus. Moreover, we have analyzed the N1 progeny of a (B6 X C58) X C58 backcross to determine the segregation of the Mtv-8 provirus with respect to polymorphisms in the Igk-VSer and Igk-J loci. The results with congenic and backcross mice together with results of others suggest that Mtv-8 is located approximately 0.52 cM from several closely linked kappa markers on chromosome 6.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cadeias kappa de Imunoglobulina
/
Vírus do Tumor Mamário do Camundongo
Limite:
Animals
Idioma:
En
Revista:
Immunogenetics
Ano de publicação:
1987
Tipo de documento:
Article