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Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group.
Zhao, Jichen; Zhang, Dehui; Zhang, Weihe; Stashko, Michael A; DeRyckere, Deborah; Vasileiadi, Eleana; Parker, Rebecca E; Hunter, Debra; Liu, Qingyang; Zhang, Yuewei; Norris-Drouin, Jacqueline; Li, Bing; Drewry, David H; Kireev, Dmitri; Graham, Douglas K; Earp, Henry Shelton; Frye, Stephen V; Wang, Xiaodong.
Afiliação
  • Zhao J; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Zhang D; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Zhang W; Meryx, Inc. , 450 West Drive , Chapel Hill , North Carolina 27599 , United States.
  • Stashko MA; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • DeRyckere D; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Vasileiadi E; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, School of Medicine , Emory University , Atlanta , Georgia 30322 , United States.
  • Parker RE; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, School of Medicine , Emory University , Atlanta , Georgia 30322 , United States.
  • Hunter D; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, School of Medicine , Emory University , Atlanta , Georgia 30322 , United States.
  • Liu Q; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
  • Zhang Y; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Norris-Drouin J; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Li B; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Drewry DH; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Kireev D; Meryx, Inc. , 450 West Drive , Chapel Hill , North Carolina 27599 , United States.
  • Graham DK; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy , Chapel Hill , North Carolina 27599 , United States.
  • Earp HS; Meryx, Inc. , 450 West Drive , Chapel Hill , North Carolina 27599 , United States.
  • Frye SV; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, School of Medicine , Emory University , Atlanta , Georgia 30322 , United States.
  • Wang X; Meryx, Inc. , 450 West Drive , Chapel Hill , North Carolina 27599 , United States.
J Med Chem ; 61(22): 10242-10254, 2018 11 21.
Article em En | MEDLINE | ID: mdl-30347155
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / C-Mer Tirosina Quinase Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / C-Mer Tirosina Quinase Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos