Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses.

Holm, Tobias; Kopicki, Janine-Denise; Busch, Carola; Olschewski, Silke; Rosenthal, Maria; Uetrecht, Charlotte; Günther, Stephan; Reindl, Sophia

Holm, Tobias; Kopicki, Janine-Denise; Busch, Carola; Olschewski, Silke; Rosenthal, Maria; Uetrecht, Charlotte; Günther, Stephan; Reindl, Sophia.

Afiliação

Holm T; From the Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.
Kopicki JD; the Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany, and.
Busch C; From the Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.
Olschewski S; From the Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.
Rosenthal M; From the Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.
Uetrecht C; the Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany, and.
Günther S; the European XFEL GmbH, 22869 Schenefeld, Germany.
Reindl S; From the Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.

J Biol Chem ; 293(51): 19686-19698, 2018 12 21.

Article em En | MEDLINE | ID: mdl-30348898

Assuntos

Endonucleases/química; Endonucleases/metabolismo; Capuzes de RNA/metabolismo; Vírus de RNA/enzimologia; Vírus de RNA/genética; RNA Viral/metabolismo; Sequência de Aminoácidos; Domínio Catalítico; Modelos Moleculares

Palavras-chave

cap-snatching; endonuclease; enzyme structure; metal ionprotein interaction; nairovirus; negative-strand RNA virus; recombinant protein expression; small-angle X-ray scattering (SAXS); structure-function; viral transcription

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus de RNA / Capuzes de RNA / RNA Viral / Endonucleases Tipo de estudo: Prognostic_studies Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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