A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.
J Exp Med
; 166(2): 341-61, 1987 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-3036997
ABSTRACT
We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos H-2
/
Genes MHC da Classe II
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Camundongos Endogâmicos BALB C
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1987
Tipo de documento:
Article