Synthesis of a Polycyclic Halichondrin C1-C14 Fragment via Intermolecular Oxy-Michael/ Trans-Ketalization.

Kim, Dae-Shik; Fang, Francis G; Choi, Hyeong-Wook; Fang, Hui

Kim, Dae-Shik; Fang, Francis G; Choi, Hyeong-Wook; Fang, Hui.

Afiliação

Kim DS; Integrated Chemistry Engine , Eisai AiM Institute , 4 Corporate Drive , Andover , Massachusetts 01810 , United States.
Fang FG; Integrated Chemistry Engine , Eisai AiM Institute , 4 Corporate Drive , Andover , Massachusetts 01810 , United States.
Choi HW; Integrated Chemistry Engine , Eisai AiM Institute , 4 Corporate Drive , Andover , Massachusetts 01810 , United States.
Fang H; Integrated Chemistry Engine , Eisai AiM Institute , 4 Corporate Drive , Andover , Massachusetts 01810 , United States.

J Org Chem ; 84(8): 4898-4903, 2019 04 19.

Article em En | MEDLINE | ID: mdl-30395467

ABSTRACT

ABSTRACT

Syntheses of a crystalline polycyclic halichondrin C1-C14 building block starting from a d-gulono-1,4-lactone-derived intermediate in the current Halaven manufacturing process are described. Key features of the syntheses include an acid-catalyzed tandem intermolecular oxy-Michael/intramolecular trans-ketalization reaction and stereoselective Kishi reductions.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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