[A phase II study of vindesine for pretreated non-small cell lung cancer].
Gan To Kagaku Ryoho
; 14(8): 2532-6, 1987 Aug.
Article
em Ja
| MEDLINE
| ID: mdl-3039921
ABSTRACT
A phase II evaluation of vindesine (VDS) was performed in 16 patients with non-small cell lung cancer (ten patients with adenocarcinoma, six patients with squamous cell carcinoma, and one patient with large cell carcinoma). All except one of the patients had had prior chemotherapy. VDS at a dose of 3 mg/m2 was given intravenously every week for more than three weeks. Among 16 evaluable patients, two patients with pretreated adenocarcinoma of the lung showed partial response. The response rate for VDS was 12.5%. Toxic effects included leukopenia (94%), anemia (44%), thrombopenia (13%), alopecia (38%), peripheral neurotoxicity (38%), liver injury (19%), constipation (13%), anorexia (13%), nausea (13%), stomatitis (6%) and fever (6%).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vindesina
/
Carcinoma de Células Pequenas
/
Neoplasias Pulmonares
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Ano de publicação:
1987
Tipo de documento:
Article