Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes.
Clin Sci (Lond)
; 132(23): 2509-2518, 2018 12 12.
Article
em En
| MEDLINE
| ID: mdl-30401689
ABSTRACT
Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Negro ou Afro-Americano
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Encéfalo
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Leucócitos Mononucleares
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Imageamento por Ressonância Magnética
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Complicações do Diabetes
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Diabetes Mellitus Tipo 2
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Metabolismo Energético
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Mitocôndrias
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Sci (Lond)
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos