Pregnancy after cancer: Does timing of conception affect infant health?
Cancer
; 124(22): 4401-4407, 2018 11 15.
Article
em En
| MEDLINE
| ID: mdl-30403424
ABSTRACT
BACKGROUND:
The objective of this retrospective cohort study was to determine whether women who conceive soon after treatment for cancer have higher risks of adverse pregnancy outcomes.METHODS:
Vital records data were linked to cancer registry diagnosis and treatment information in 3 US states. Women who conceived their first pregnancy after diagnosis between ages 20 and 45 years with any invasive cancer or ductal carcinoma in situ were eligible. Log-binomial models were used to compare risks in cancer survivors who conceived in each interval to the risks in matched comparison births to women without cancer.RESULTS:
Women who conceived ≤1 year after starting chemotherapy for any cancer had higher risks of preterm birth than comparison women (chemotherapy alone relative risk [RR], 1.9; 95% confidence interval [CI], 1.3-2.7; chemotherapy with radiation RR, 2.4; 95% CI, 1.6-3.6); women who conceived ≥1 year after starting chemotherapy without radiation or ≥2 years after chemotherapy with radiation did not. In analyses imputing the treatment end date for breast cancer survivors, those who conceived ≥1 year after finishing chemotherapy with or without radiation had no higher risks than women without cancer. The risk of preterm birth in cervical cancer survivors largely persisted but was somewhat lower in pregnancies conceived after the first year (for pregnancies conceived ≤1 year after diagnosis RR, 3.5; 95% CI, 2.2-5.4; for pregnancies conceived >1 year after diagnosis RR, 2.4; 95% CI, 1.6-3.5).CONCLUSIONS:
In women who received chemotherapy, the higher risk of preterm birth was limited to those survivors who had short intervals between treatment and conception.Cancer 2018;124000-000.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resultado da Gravidez
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Nascimento Prematuro
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Sobreviventes de Câncer
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Antineoplásicos
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Cancer
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Geórgia