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Determining minimal output sets that ensure structural identifiability.
Joubert, D; Stigter, J D; Molenaar, J.
Afiliação
  • Joubert D; Wageningen University and Research, Biometris, Department of Mathematical and Statistical Methods, Wageningen, The Netherlands.
  • Stigter JD; Wageningen University and Research, Biometris, Department of Mathematical and Statistical Methods, Wageningen, The Netherlands.
  • Molenaar J; Wageningen University and Research, Biometris, Department of Mathematical and Statistical Methods, Wageningen, The Netherlands.
PLoS One ; 13(11): e0207334, 2018.
Article em En | MEDLINE | ID: mdl-30419074
ABSTRACT
The process of inferring parameter values from experimental data can be a cumbersome task. In addition, the collection of experimental data can be time consuming and costly. This paper covers both these issues by addressing the following question "Which experimental outputs should be measured to ensure that unique model parameters can be calculated?". Stated formally, we examine the topic of minimal output sets that guarantee a model's structural identifiability. To that end, we introduce an algorithm that guides a researcher as to which model outputs to measure. Our algorithm consists of an iterative structural identifiability analysis and can determine multiple minimal output sets of a model. This choice in different output sets offers researchers flexibility during experimental design. Our method can determine minimal output sets of large differential equation models within short computational times.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Algoritmos / Modelos Teóricos Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Algoritmos / Modelos Teóricos Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda