Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.
Virology
; 526: 214-221, 2019 01 02.
Article
em En
| MEDLINE
| ID: mdl-30419515
ABSTRACT
Transcriptional coactivators represent critical components of the transcriptional pre-initiation complex and are required for efficient gene activation. Members of the peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) family differentially regulate hepatitis b virus (HBV) biosynthesis. Whereas PGC1α has been shown to be a potent activator of HBV biosynthesis, PGC1ß only very poorly activates HBV RNA and DNA synthesis in human hepatoma (HepG2) and embryonic kidney (HEK293T) cells. Furthermore, PGC1ß inhibits PGC1α-mediated HBV biosynthesis. These observations suggest that a potential competition between human hepatoma (HepG2) and embryonic kidney (HEK293T) cells PGC1α and PGC1ß for common transcription factor target(s) may regulate HBV transcription and replication in a context and signal transduction pathway dependent manner.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Replicação Viral
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Proteínas de Transporte
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Vírus da Hepatite B
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Interações Hospedeiro-Patógeno
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Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo
Limite:
Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos