Cytotoxic Activity of Compounds from Styrax obassia.

ABSTRACT

Cancer is a major public health burden in both developed and developing countries. Plant-derived compounds have played an important role in the development of useful anti-cancer agents. The current study was designed to evaluate the cytotoxic activity of chemical compounds from the stem bark of Styrax obassia. Seven known compounds (1-7) were isolated and identified. Compound 2 exhibited cytotoxic activity against the breast cancer cell line MCF-7 with an IC550 of 27.9 µM, followed by the human cervical cancer cell line Hela with an IC50 of 23.3 µM, and the human promyelocytic leukemia cell line HL-60 with an IC50 of 47.8 RM. Compound 7 exhibited cytotoxicity against Hela cells with an ICso of 16.8 pM, followed by MCF-7 cells with an IC50 of 53.5 µM. This is the first study to investigate the significant anti-tumor properties of isolated compounds from the stem bark of S. obassia.