DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.

Scutts, Simon R; Ember, Stuart W; Ren, Hongwei; Ye, Chao; Lovejoy, Christopher A; Mazzon, Michela; Veyer, David L; Sumner, Rebecca P; Smith, Geoffrey L

Scutts, Simon R; Ember, Stuart W; Ren, Hongwei; Ye, Chao; Lovejoy, Christopher A; Mazzon, Michela; Veyer, David L; Sumner, Rebecca P; Smith, Geoffrey L.

Afiliação

Scutts SR; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Ember SW; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Ren H; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Ye C; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Lovejoy CA; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Mazzon M; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Veyer DL; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Sumner RP; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Smith GL; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. Electronic address: gls37@cam.ac.uk.

Cell Rep ; 25(7): 1953-1965.e4, 2018 11 13.

Article em En | MEDLINE | ID: mdl-30428360

Assuntos

Proteína Quinase Ativada por DNA/metabolismo; DNA/metabolismo; Vaccinia virus/metabolismo; Proteínas Virais/metabolismo; Administração Intranasal; Animais; Citocinas/metabolismo; Proteína Quinase Ativada por DNA/química; Feminino; Células HEK293; Células HeLa; Humanos; Imunidade Inata; Autoantígeno Ku/metabolismo; Ativação Linfocitária/imunologia; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Mutagênese Sítio-Dirigida; Ligação Proteica; Multimerização Proteica; Linfócitos T/imunologia; Vaccinia virus/patogenicidade; Virulência

Palavras-chave

DNA protein kinase; DNA sensing; IRF3 signaling; immune evasion; pattern recognition receptor; protein C4; vaccinia virus; virulence factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vaccinia virus / Proteínas Virais / DNA / Proteína Quinase Ativada por DNA Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

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