Genomic Characterization of ß-Glucuronidase-Positive Escherichia coli O157:H7 Producing Stx2a.
Emerg Infect Dis
; 24(12): 2219-2227, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30457544
ABSTRACT
Among Shiga toxin (Stx)-producing Escherichia coli (STEC) O157H7 strains, those producing Stx2a cause more severe diseases. Atypical STEC O157H7 strains showing a ß-glucuronidase-positive phenotype (GP STEC O157H7) have rarely been isolated from humans, mostly from persons with asymptomatic or mild infections; Stx2a-producing strains have not been reported. We isolated, from a patient with bloody diarrhea, a GP STEC O157H7 strain (PV15-279) that produces Stx2a in addition to Stx1a and Stx2c. Genomic comparison with other STEC O157 strains revealed that PV15-279 recently emerged from the stx1a/stx2c-positive GP STEC O157H7 clone circulating in Japan. Major virulence genes are shared between typical (ß-glucuronidase-negative) and GP STEC O157H7 strains, and the Stx2-producing ability of PV15-279 is comparable to that of typical STEC O157H7 strains; therefore, PV15-279 presents a virulence potential similar to that of typical STEC O157H7. This study reveals the importance of GP O157H7 as a source of highly pathogenic STEC clones.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Bacteriano
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Escherichia coli O157
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Toxina Shiga II
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Genômica
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Infecções por Escherichia coli
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Glucuronidase
Idioma:
En
Revista:
Emerg Infect Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2018
Tipo de documento:
Article