A pH-driven ring translocation switch against cancer cells.
Chem Commun (Camb)
; 54(98): 13825-13828, 2018 Dec 06.
Article
em En
| MEDLINE
| ID: mdl-30462104
ABSTRACT
A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viologênios
/
Hidrocarbonetos Aromáticos com Pontes
/
Sobrevivência Celular
/
Imidazóis
/
Neoplasias
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China