Itraconazole Attenuates Peritoneal Fibrosis Through Its Effect on the Sonic Hedgehog Signaling Pathway in Mice.

Kim, Jin Sug; Cho, Kyung Sook; Park, Seon Hwa; Lee, Sang Ho; Lee, Ji Hwan; Jeong, Kyung Hwan; Lee, Tae Won

Kim, Jin Sug; Cho, Kyung Sook; Park, Seon Hwa; Lee, Sang Ho; Lee, Ji Hwan; Jeong, Kyung Hwan; Lee, Tae Won.

Afiliação

Kim JS; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea.
Cho KS; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea.
Park SH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.
Lee SH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.
Lee JH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea.
Jeong KH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea.
Lee TW; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea, kidwon@khmc.or.kr.

Am J Nephrol ; 48(6): 456-464, 2018.

Article em En | MEDLINE | ID: mdl-30472702

Assuntos

Proteínas Hedgehog/metabolismo; Itraconazol/farmacologia; Diálise Peritoneal/efeitos adversos; Fibrose Peritoneal/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos; Animais; Clorexidina/administração & dosagem; Clorexidina/análogos & derivados; Clorexidina/toxicidade; Modelos Animais de Doenças; Humanos; Injeções Intraperitoneais; Itraconazol/uso terapêutico; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Fibrose Peritoneal/induzido quimicamente; Fibrose Peritoneal/patologia; Peritônio/efeitos dos fármacos; Peritônio/patologia; Resultado do Tratamento

Palavras-chave

Itraconazole; Peritoneal dialysis; Peritoneal fibrosis; Sonic hedgehog signaling pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Diálise Peritoneal / Itraconazol / Proteínas Hedgehog / Fibrose Peritoneal Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Am J Nephrol Ano de publicação: 2018 Tipo de documento: Article

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