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DosR proteins of Mycobacterium tuberculosis upregulate effector T cells and down regulate T regulatory cells in TB patients and their healthy contacts.
Pandey, Kirti; Singh, Swati; Bhatt, Parul; Sharma, Monika; Chaudhry, Anil; Sharma, Sadhna.
Afiliação
  • Pandey K; DS Kothari Centre for Research and Innovation in Science Education, Miranda House, and Department of Zoology, Miranda House, University of Delhi, Delhi, 110007, India. Electronic address: kirti.pandey5@gmail.com.
  • Singh S; DS Kothari Centre for Research and Innovation in Science Education, Miranda House, and Department of Zoology, Miranda House, University of Delhi, Delhi, 110007, India. Electronic address: singhswati.mh@gmail.com.
  • Bhatt P; DS Kothari Centre for Research and Innovation in Science Education, Miranda House, and Department of Zoology, Miranda House, University of Delhi, Delhi, 110007, India. Electronic address: bhattparul1@gmail.com.
  • Medha; DS Kothari Centre for Research and Innovation in Science Education, Miranda House, and Department of Zoology, Miranda House, University of Delhi, Delhi, 110007, India. Electronic address: mmedha18@gmail.com.
  • Sharma M; DS Kothari Centre for Research and Innovation in Science Education, Miranda House, and Department of Zoology, Miranda House, University of Delhi, Delhi, 110007, India. Electronic address: monikasharma.mh@gmail.com.
  • Chaudhry A; Rajan Babu Institute of Pulmonary Medicine and Tuberculosis Hospital, GTB Nagar, Delhi, 110009, India. Electronic address: dranilchaudhry@gmail.com.
  • Sharma S; DS Kothari Centre for Research and Innovation in Science Education, Miranda House, and Department of Zoology, Miranda House, University of Delhi, Delhi, 110007, India. Electronic address: sadhna.sharma@mirandahouse.ac.in.
Microb Pathog ; 126: 399-406, 2019 Jan.
Article em En | MEDLINE | ID: mdl-30476579
It is well established that the current problem of tuberculosis (TB) can be combated by overcoming the drawbacks of the currently available BCG vaccine. This would involve incorporation of antigens that can control TB at all stages including the dormant phase which is generally ignored. Hence, DosR regulon proteins, which are expressed in latent infection, could prove to be very good vaccine candidates as they can possibly target the silent but most predominant form of TB infection. In the present study, the immune response to two DosR proteins Rv2627 and Rv2628 has been studied in PBMCs derived from normal individuals, TB patients and healthy contacts of TB patients. It was found that these antigens were capable of stimulating a strong IFN-γ+ T cell response along with accentuation of memory T cells and other protective cytokines such as IL-2 and IL-17. At the same time these proteins decreased the frequencies of immune-suppressor regulatory T cells in in vitro stimulation of PBMC from both patients and their contacts. Considering all these facts together, we suggest Rv2627 and Rv2628 to be one of the extremely promising candidates for incorporation into a post exposure subunit vaccine against TB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Proteínas de Bactérias / Tuberculose / Linfócitos T / Linfócitos T Reguladores / Mycobacterium tuberculosis / Antígenos de Bactérias Limite: Humans Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Proteínas de Bactérias / Tuberculose / Linfócitos T / Linfócitos T Reguladores / Mycobacterium tuberculosis / Antígenos de Bactérias Limite: Humans Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article