Big bottlenecks in cardiovascular tissue engineering.

Huang, Ngan F; Serpooshan, Vahid; Morris, Viola B; Sayed, Nazish; Pardon, Gaspard; Abilez, Oscar J; Nakayama, Karina H; Pruitt, Beth L; Wu, Sean M; Yoon, Young-Sup; Zhang, Jianyi; Wu, Joseph C

Huang, Ngan F; Serpooshan, Vahid; Morris, Viola B; Sayed, Nazish; Pardon, Gaspard; Abilez, Oscar J; Nakayama, Karina H; Pruitt, Beth L; Wu, Sean M; Yoon, Young-Sup; Zhang, Jianyi; Wu, Joseph C.

Afiliação

Huang NF; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA. ngantina@stanford.edu.
Serpooshan V; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, 94305, CA, USA. ngantina@stanford.edu.
Morris VB; Veteran Affairs Palo Alto Health Care System, Palo Alto, 94304, CA, USA. ngantina@stanford.edu.
Sayed N; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA.
Pardon G; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, 30332, GA, USA.
Abilez OJ; Department of Pediatrics, Emory University School of Medicine, Atlanta, 30307, GA, USA.
Nakayama KH; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, 30332, GA, USA.
Pruitt BL; Department of Medicine, Division of Cardiology, Emory University, Atlanta, 30307, GA, USA.
Wu SM; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA.
Yoon YS; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA.
Zhang J; Department of Bioengineering, Stanford University, Stanford, 94305, CA, USA.
Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA.

Commun Biol ; 1: 199, 2018.

Article em En | MEDLINE | ID: mdl-30480100

ABSTRACT

ABSTRACT

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Commun Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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