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Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Lang, Charmaine; Campbell, Kieran R; Ryan, Brent J; Carling, Phillippa; Attar, Moustafa; Vowles, Jane; Perestenko, Olga V; Bowden, Rory; Baig, Fahd; Kasten, Meike; Hu, Michele T; Cowley, Sally A; Webber, Caleb; Wade-Martins, Richard.
Afiliação
  • Lang C; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK.
  • Campbell KR; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Ryan BJ; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK.
  • Carling P; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK.
  • Attar M; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Vowles J; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
  • Perestenko OV; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
  • Bowden R; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Baig F; Oxford Parkinson's Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Kasten M; Department of Psychiatry and Psychotherapy and Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
  • Hu MT; Oxford Parkinson's Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Cowley SA; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
  • Webber C; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK. Electronic address: webberc4@cardiff.ac.uk.
  • Wade-Martins R; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK. Electronic address: richard.wade-martins@dpag.ox.ac.uk.
Cell Stem Cell ; 24(1): 93-106.e6, 2019 01 03.
Article em En | MEDLINE | ID: mdl-30503143
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Repressoras / Regulação da Expressão Gênica / Células-Tronco Pluripotentes Induzidas / Análise de Célula Única / Neurônios Dopaminérgicos / Histona Desacetilases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Repressoras / Regulação da Expressão Gênica / Células-Tronco Pluripotentes Induzidas / Análise de Célula Única / Neurônios Dopaminérgicos / Histona Desacetilases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido