Clinicopathological and prognostic significance of GLUT1 in breast cancer: A meta-analysis.

ABSTRACT

BACKGROUND: Previous studies examining the prognostic value of glucose transporter 1 in breast cancer have yielded inconsistent results. We, therefore, performed a meta-analysis to clarify this issue. METHODS: The research was reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Relevant studies were retrieved from PubMed, Web of Science, EMBASE, and Cochrane library. RESULTS: A total of 7 reports with 1861 patients were finally chosen. GLUT1 overexpression was found to be associated with high histological grade (OR = 3.74, 95% CI = 2.45-5.69, P < .001), negative PR status (OR = 0.33, 95% CI = 0.22-0.49, P < .001), and negative estrogen receptor (ER) status (OR = 0.27, 95% CI = 0.17-0.42, P < .001). However, no significant correlation was seen between GLUT1 levels and presence of lymph node metastasis, tumor size or the status of human epidermal growth factor receptor 2 (HER2). Overexpression of GLUT1 also correlated with a poor overall survival (hazard ratio [HR] = 1.65, 95% confidence interval [CI] = 1.17-2.31, P = .004) and disease-free survival (HR = 2.35, 95% CI = 1.4-3.94, P < .001). No evidence of significant publication bias was found. CONCLUSION: This meta-analysis indicates that GLUT1 expression is associated with poor prognostic and a series of clinicopathological features in breast cancer. GLUT1 might be a potential biomarker and therapeutic target in breast cancer.