A Vinyl-Boronate Ester-Based Persulfide Donor Controllable by Hydrogen Peroxide, a Reactive Oxygen Species (ROS).

Bora, Prerona; Chauhan, Preeti; Manna, Suman; Chakrapani, Harinath

Bora, Prerona; Chauhan, Preeti; Manna, Suman; Chakrapani, Harinath.

Afiliação

Bora P; Department of Chemistry , Indian Institute of Science Education and Research Pune , Pune 411 008 , Maharashtra , India.
Chauhan P; Department of Chemistry , Indian Institute of Science Education and Research Pune , Pune 411 008 , Maharashtra , India.
Manna S; Department of Chemistry , Indian Institute of Science Education and Research Pune , Pune 411 008 , Maharashtra , India.
Chakrapani H; Department of Chemistry , Indian Institute of Science Education and Research Pune , Pune 411 008 , Maharashtra , India.

Org Lett ; 20(24): 7916-7920, 2018 12 21.

Article em En | MEDLINE | ID: mdl-30525675

ABSTRACT

ABSTRACT

A vinyl boronate ester-based persulfidating agent that is selectively activated by hydrogen peroxide, which is a reactive oxygen species (ROS), and efficiently generated a persulfide by a hitherto unexplored 1,4-O,S-relay mechanism is reported. This donor was found to protect cells from cytotoxicity induced by oxidants, and the major byproduct is cinnamaldehyde, which is widely used in the food industry as an additive.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia

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