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Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma.
Kurake, Naoyuki; Ishikawa, Kenji; Tanaka, Hiromasa; Hashizume, Hiroshi; Nakamura, Kae; Kajiyama, Hiroaki; Toyokuni, Shinya; Kikkawa, Fumitaka; Mizuno, Masaaki; Hori, Masaru.
Afiliação
  • Kurake N; Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8603, Japan.
  • Ishikawa K; Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8603, Japan; Plasma Medical Science Global Innovation Center, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan. Electronic address: ishikawa.kenji@nagoya-u.jp.
  • Tanaka H; Plasma Medical Science Global Innovation Center, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan.
  • Hashizume H; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan.
  • Nakamura K; Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa, Nagoya, 466-8550, Japan.
  • Kajiyama H; Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa, Nagoya, 466-8550, Japan.
  • Toyokuni S; Plasma Medical Science Global Innovation Center, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan; Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa, Nagoya, 466-8550, Japan.
  • Kikkawa F; Plasma Medical Science Global Innovation Center, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan; Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa, Nagoya, 466-8550, Japan.
  • Mizuno M; Plasma Medical Science Global Innovation Center, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, 65 Tsurumai-cho, Showa, Nagoya, 466-8560, Japan.
  • Hori M; Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8603, Japan; Plasma Medical Science Global Innovation Center, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa, Nagoya, 484
Arch Biochem Biophys ; 662: 83-92, 2019 02 15.
Article em En | MEDLINE | ID: mdl-30528778
ABSTRACT
Non-equilibrium atmospheric pressure plasma (NEAPP) is a mixture of radicals, electrons, anions, cations and light at near body temperature. Plasma-activated medium (PAM) is realized using NEAPP provided by engineered devices and irradiated to a cell culture medium for a period of 600 s. Glioblastoma cells U251SP cultivated in PAM previously indicated that antitumor effects induced PAM-specific apoptotic cell-death. Metabolomic profiles of a hundred intracellular metabolites were analyzed using capillary electrophoresis mass spectrometry. The metabolomic profiles of the PAM-treated U251SP cells were changed significantly with inhibition of the glycolysis pathway and with enhancement of the pentose phosphate pathway.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Metabolômica / Gases em Plasma Limite: Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Metabolômica / Gases em Plasma Limite: Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão