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Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.
Zogota, Rimants; Kinena, Linda; Withers-Martinez, Chrislaine; Blackman, Michael J; Bobrovs, Raitis; Pantelejevs, Teodors; Kanepe-Lapsa, Iveta; Ozola, Vita; Jaudzems, Kristaps; Suna, Edgars; Jirgensons, Aigars.
Afiliação
  • Zogota R; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia.
  • Kinena L; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia.
  • Withers-Martinez C; Malaria Biochemistry Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • Blackman MJ; Malaria Biochemistry Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
  • Bobrovs R; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia.
  • Pantelejevs T; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia.
  • Kanepe-Lapsa I; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia.
  • Ozola V; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia.
  • Jaudzems K; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia.
  • Suna E; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia. Electronic address: edgars@osi.lv.
  • Jirgensons A; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV, 1006, Latvia. Electronic address: aigars@osi.lv.
Eur J Med Chem ; 163: 344-352, 2019 Feb 01.
Article em En | MEDLINE | ID: mdl-30529637
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aspártico Endopeptidases / Catepsina D / Peptidomiméticos / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Letônia
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aspártico Endopeptidases / Catepsina D / Peptidomiméticos / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Letônia