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Multi-length scale bioprinting towards simulating microenvironmental cues.
Gill, Elisabeth L; Li, Xia; Birch, Mark A; Huang, Yan Yan Shery.
Afiliação
  • Gill EL; 1Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ UK.
  • Li X; 1Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ UK.
  • Birch MA; 2Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Cambridge, UK.
  • Huang YYS; 1Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ UK.
Biodes Manuf ; 1(2): 77-88, 2018.
Article em En | MEDLINE | ID: mdl-30546920
It is envisaged that the creation of cellular environments at multiple length scales, that recapitulate in vivo bioactive and structural roles, may hold the key to creating functional, complex tissues in the laboratory. This review considers recent advances in biofabrication and bioprinting techniques across different length scales. Particular focus is placed on 3D printing of hydrogels and fabrication of biomaterial fibres that could extend the feature resolution and material functionality of soft tissue constructs. The outlook from this review discusses how one might create and simulate microenvironmental cues in vitro. A fabrication platform that integrates the competencies of different biofabrication technologies is proposed. Such a multi-process, multiscale fabrication strategy may ultimately translate engineering capability into an accessible life sciences toolkit, fulfilling its potential to deliver in vitro disease models and engineered tissue implants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biodes Manuf Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biodes Manuf Ano de publicação: 2018 Tipo de documento: Article