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ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.
Ojha, Rani; Leli, Nektaria M; Onorati, Angelique; Piao, Shengfu; Verginadis, Ioannis I; Tameire, Feven; Rebecca, Vito W; Chude, Cynthia I; Murugan, Sengottuvelan; Fennelly, Colin; Noguera-Ortega, Estela; Chu, Charleen T; Liu, Shujing; Xu, Xiaowei; Krepler, Clemens; Xiao, Min; Xu, Wei; Wei, Zhi; Frederick, Dennie T; Boland, Genevieve; Mitchell, Tara C; Karakousis, Giorgos C; Schuchter, Lynn M; Flaherty, Keith T; Zhang, Gao; Herlyn, Meenhard; Koumenis, Constantinos; Amaravadi, Ravi K.
Afiliação
  • Ojha R; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Leli NM; Department of Radiation Oncology, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Onorati A; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Piao S; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Verginadis II; Department of Radiation Oncology, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Tameire F; Department of Radiation Oncology, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Rebecca VW; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Chude CI; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Murugan S; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Fennelly C; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Noguera-Ortega E; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Chu CT; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Liu S; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Xu X; Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Krepler C; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.
  • Xiao M; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.
  • Xu W; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Wei Z; Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.
  • Frederick DT; Massachusetts General Hospital, Harvard University, Boston, Massachusetts.
  • Boland G; Massachusetts General Hospital, Harvard University, Boston, Massachusetts.
  • Mitchell TC; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Karakousis GC; Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Schuchter LM; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Flaherty KT; Massachusetts General Hospital, Harvard University, Boston, Massachusetts.
  • Zhang G; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.
  • Herlyn M; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.
  • Koumenis C; Department of Radiation Oncology, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Amaravadi RK; Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Ravi.amaravadi@uphs.upenn.edu.
Cancer Discov ; 9(3): 396-415, 2019 03.
Article em En | MEDLINE | ID: mdl-30563872
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema de Sinalização das MAP Quinases / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Retículo Endoplasmático / Melanoma / Mutação Limite: Animals / Humans / Male Idioma: En Revista: Cancer Discov Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema de Sinalização das MAP Quinases / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Retículo Endoplasmático / Melanoma / Mutação Limite: Animals / Humans / Male Idioma: En Revista: Cancer Discov Ano de publicação: 2019 Tipo de documento: Article