Antiproliferative 3-deoxysphingomyelin analogs: Design, synthesis, biological evaluation and molecular docking of pyrrolidine-based 3-deoxysphingomyelin analogs as anticancer agents.

Hassan, Ahmed H E; Park, Hye Rim; Yoon, Yoon Mi; Kim, Hye In; Yoo, Sung Yeun; Lee, Kun Won; Lee, Yong Sup

Hassan, Ahmed H E; Park, Hye Rim; Yoon, Yoon Mi; Kim, Hye In; Yoo, Sung Yeun; Lee, Kun Won; Lee, Yong Sup.

Afiliação

Hassan AHE; Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Park HR; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee University, Seoul 02447, Republic of Korea.
Yoon YM; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee University, Seoul 02447, Republic of Korea.
Kim HI; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee University, Seoul 02447, Republic of Korea.
Yoo SY; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee University, Seoul 02447, Republic of Korea.
Lee KW; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee University, Seoul 02447, Republic of Korea.
Lee YS; Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: kyslee@khu.ac.kr.

Bioorg Chem ; 84: 444-455, 2019 03.

Article em En | MEDLINE | ID: mdl-30576908

Assuntos

Antineoplásicos/síntese química; Desenho de Fármacos; Pirrolidinas/química; Esfingomielinas/química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Sítios de Ligação; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Simulação de Acoplamento Molecular; Fosforilação/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Esfingomielinas/metabolismo; Esfingomielinas/farmacologia; Relação Estrutura-Atividade

Palavras-chave

3-Deoxysphingomyelin analogs; Akt phosphorylation; Antiproliferative agents; Bioactive lipids

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Esfingomielinas / Desenho de Fármacos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Egito

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google