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VEGF gene rs3025039C/T and rs833052C/A variants are associated with bladder cancer risk in Asian descendants.
Zhang, Li-Feng; Ren, Ke-Wei; Zuo, Li; Zou, Jian-Gang; Song, Ning-Hong; Mi, Yuan-Yuan; Wang, Zeng-Jun; Zhang, Wei.
Afiliação
  • Zhang LF; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
  • Ren KW; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Zuo L; Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin, China.
  • Zou JG; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
  • Song NH; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
  • Mi YY; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Wang ZJ; Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, China.
  • Zhang W; Department of Urology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
J Cell Biochem ; 120(6): 10402-10412, 2019 06.
Article em En | MEDLINE | ID: mdl-30609111
ABSTRACT

INTRODUCTION:

Polymorphisms of vascular endothelial growth factor (VEGF) gene were evaluated in a number of studies to evaluate bladder cancer (BCa) susceptibility but with controversial conclusions. MATERIAL AND

METHODS:

We performed a pooled analysis and used odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) to investigate the correlation between VEGF gene rs3025039C/T and rs833052C/A variants and risk of BCa. Furthermore, we utilized in silico tools to demonstrate the relationship of VEGF expression correlated with BCa susceptibility and survival time.

RESULTS:

A total of eight studies including 4359 BCa patients and 5417 control subjects were enrolled in our study. For VEGF rs3025039C/T, a significant association was indicated between this variant and BCa risk in homozygote comparison (OR = 1.51; 95% CI = 1.13-2.02; P heterogeneity = 0.815) and recessive genetic model (OR = 1.49; 95% CI = 1.12-1.99; P heterogeneity = 0.874), in particular in an Asian population subgroup. For VEGF rs833052C/A, we observed a positive association between this variant and BCa susceptibility in Asian descendants. Results from in silico tool showed evidence that VEGF expression in bladder carcinoma tissue is higher than that in normal counterpart (transcripts per kilobase million = 7.21 vs 6.85; P < 0.05).

CONCLUSIONS:

The VEGF gene rs3025039C/T and rs833052C/A variants may contribute to the risk of developing BCa, especially in Asian descendants. Future larger sample studies should be continued to focus on this issue in more detail.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Fator A de Crescimento do Endotélio Vascular / Povo Asiático Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Cell Biochem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Fator A de Crescimento do Endotélio Vascular / Povo Asiático Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Cell Biochem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China