Copper-Catalyzed Remote C(sp3 )-H Trifluoromethylation of Carboxamides and Sulfonamides.
Angew Chem Int Ed Engl
; 58(8): 2510-2513, 2019 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-30614163
ABSTRACT
Reported herein is an unprecedented protocol for trifluoromethylation of unactivated aliphatic C(sp3 )-H bonds. With Cu(OTf)2 as the catalyst, the reaction of N-fluoro-substituted carboxamides (or sulfonamides) with Zn(CF3 )2 complexes provides the corresponding δ-trifluoromethylated carboxamides (or sulfonamides) in satisfactory yields under mild reaction conditions. A radical mechanism involving 1,5-hydrogen atom transfer of N-radicals followed by CF3 -transfer from CuII -CF3 complexes to the thus formed alkyl radicals is proposed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2019
Tipo de documento:
Article