Serum level of macrophage migration inhibitory factor predicts severity and prognosis in patients with ischemic stroke.
Cytokine
; 115: 8-12, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30616035
ABSTRACT
OBJECTIVE:
To evaluate whether the macrophage migration inhibitory factor (MIF) level in serum of ischemic stroke patients was associated with their clinical severity and early outcome.METHODS:
During February 2017-March 2018, consecutive patients admitted to our hospital because of first-ever ischemic stroke were identified. The prognostic value of MIF was set for predicting the outcome of these patients at discharge. The results were compared with existing methods, including National Institutes of Health Stroke Scale (NIHSS) score and validated indicators.RESULTS:
289 patients were enrolled. The serum level of all patients was determined (median 20.6â¯ng/ml). At admission, 131 patients (45.3%) were evaluated as minor stroke (NIHSSâ¯<â¯5). When serum level of MIF was increased by each 1â¯ng/ml, the unadjusted and adjusted risk of moderate-to-high clinical severity was elevated by 5% (ORâ¯=â¯1.05 [95% CI 1.01-1.09], Pâ¯=â¯0.006) and 3% (1.03 [1.00-1.08], Pâ¯=â¯0.02), respectively. At discharge, 82 patients (28.4%) had poor functional outcomes. The median serum level of MIF was lower in group with good outcomes than that observed in poor outcomes (19.4[15.8-24.2] vs. 24.0[19.9-29.4]â¯ng/ml; Pâ¯<â¯0.001). When serum level of MIF was increased by each 1â¯ng/ml, the unadjusted and adjusted risk of poor outcomes was elevated by 9% (1.09 [1.05-1.13], Pâ¯<â¯0.001) and 6% (1.06 [1.02-1.10], Pâ¯<â¯0.01), respectively.CONCLUSIONS:
High MIF levels are independently related to the moderate to high clinical severity in ischemic stroke patients, as well as the poor outcome at discharge.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isquemia Encefálica
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Fatores Inibidores da Migração de Macrófagos
/
Oxirredutases Intramoleculares
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Acidente Vascular Cerebral
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cytokine
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China