Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.

Schips, Tobias G; Vanhoutte, Davy; Vo, Alexander; Correll, Robert N; Brody, Matthew J; Khalil, Hadi; Karch, Jason; Tjondrokoesoemo, Andoria; Sargent, Michelle A; Maillet, Marjorie; Ross, Robert S; Molkentin, Jeffery D

Schips, Tobias G; Vanhoutte, Davy; Vo, Alexander; Correll, Robert N; Brody, Matthew J; Khalil, Hadi; Karch, Jason; Tjondrokoesoemo, Andoria; Sargent, Michelle A; Maillet, Marjorie; Ross, Robert S; Molkentin, Jeffery D.

Afiliação

Schips TG; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Vanhoutte D; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Vo A; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Correll RN; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Brody MJ; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Khalil H; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Karch J; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Tjondrokoesoemo A; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Sargent MA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Maillet M; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Ross RS; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Molkentin JD; Division of Cardiology, Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA, 92093, USA.

Nat Commun ; 10(1): 76, 2019 01 08.

Article em En | MEDLINE | ID: mdl-30622267

Assuntos

Cardiomiopatias/patologia; Integrinas/metabolismo; Sarcolema/patologia; Trombospondinas/metabolismo; Animais; Células COS; Cardiomiopatias/diagnóstico por imagem; Cardiomiopatias/etiologia; Células Cultivadas; Chlorocebus aethiops; Modelos Animais de Doenças; Distroglicanas/metabolismo; Ecocardiografia; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Mutação; Miócitos Cardíacos; Cultura Primária de Células; Domínios e Motivos de Interação entre Proteínas/genética; Ratos; Ratos Sprague-Dawley; Sarcolema/metabolismo; Trombospondinas/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcolema / Integrinas / Trombospondinas / Cardiomiopatias Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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