The Canadian Dementia Imaging Protocol: Harmonizing National Cohorts.
J Magn Reson Imaging
; 49(2): 456-465, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30635988
ABSTRACT
BACKGROUND:
Harmonized protocols to collect imaging data must be devised, employed, and maintained in multicentric studies to reduce interscanner variability in subsequent analyses.PURPOSE:
To present a standardized protocol for multicentric research on dementia linked to neurodegeneration in aging, harmonized on all three major vendor platforms. The protocol includes a common procedure for qualification, quality control, and quality assurance and feasibility in large-scale studies. STUDY TYPE Prospective.SUBJECTS:
The study involved a geometric phantom, a single individual volunteer, and 143 cognitively healthy, mild cognitively impaired, and Alzheimer's disease participants in a large-scale, multicentric study. FIELD STRENGTH/SEQUENCES MRI was perform with 3T scanners (GE, Philips, Siemens) and included 3D T1 w, PD/T2 w, T2* , T2 w-FLAIR, diffusion, and BOLD resting state acquisitions. ASSESSMENT Measures included signal- and contrast-to-noise ratios (SNR and CNR, respectively), total brain volumes, and total scan time. STATISTICAL TESTS SNR, CNR, and scan time were compared between scanner vendors using analysis of variance (ANOVA) and Tukey tests, while brain volumes were tested using linear mixed models.RESULTS:
Geometric phantom T1 w SNR was significantly (P < 0.001) higher in Philips (mean 71.4) than Siemens (29.5), while no significant difference was observed between vendors for T2 w (32.0 and 37.2, respectively, P = 0.243). Single individual volunteer T1 w CNR was higher in subcortical regions for Siemens (P < 0.001), while Philips had higher cortical CNR (P = 0.044). No significant difference in brain volumes was observed between vendors (P = 0.310/0.582/0.055). The average scan time was 41.0 minutes (SD 2.8) and was not significantly different between sites (P = 0.071) and cognitive groups (P = 0.853). DATACONCLUSION:
The harmonized Canadian Dementia Imaging Protocol suits the needs of studies that need to ensure quality MRI data acquisition for the measurement of brain changes across adulthood, due to aging, neurodegeneration, and other etiologies. A detailed description, exam cards, and operators' manual are freely available at the following site www.cdip-pcid.ca. LEVEL OF EVIDENCE 2 Technical Efficacy Stage 2 J. Magn. Reson. Imaging 2019;49456-465.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Imageamento por Ressonância Magnética
/
Doenças Neurodegenerativas
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Demência
/
Doença de Alzheimer
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Magn Reson Imaging
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá